We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Probenecid?

By D. Jeffress
Updated May 17, 2024
Our promise to you
WiseGEEK is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGEEK, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Probenecid is a prescription drug most commonly used to ease symptoms of chronic gout and to make acute attacks less likely to occur. It may also be used in combination with certain antibiotics such as penicillin to make them more effective. Probenecid helps the body eliminate more uric acid through the urine so it does not build up in the kidneys and bloodstream and lead to gout attacks. As an antibiotic enhancer, it helps the drugs stay in a person's system longer instead of being excreted in the urine. The medication is highly effective in most cases and only rarely causes significant side effects.

People who suffer from gout attacks either produce too much uric acid or have trouble passing enough of the substance as waste. Probenecid helps the kidneys better process high levels of uric acid and prevents the organs from allowing acid to be absorbed back into the bloodstream. The fact that the drug blocks re-absorption sites in the kidneys also makes it an effective antibiotic enhancer. Antibiotics essentially become trapped in blood circulation and cannot be processed by the kidneys.

Probenecid is most commonly taken by mouth in the form of an oral tablet or capsule. Adult patients with gout are usually instructed to take one tablet a day for the first week of treatment, and one every 12 hours thereafter. Dosage amounts and frequencies may be different for patients taking antibiotics, and a doctor can determine the appropriate quantity to prescribe based on several different factors. Depending on a person's response to the drug, he or she may only need to take it for a few weeks or remain on a treatment schedule indefinitely. Doctors generally advise their patients to consume at least six glasses of water a day when taking probenecid to aid in thoroughly flushing the kidneys.

Most people who take probenecid do not experience negative side effects. Increased urination is likely to occur when consuming large amounts of water daily. Other potential side effects may include mild headaches, dizziness, nausea, vomiting, and stomach upset. Some patients also experience weight loss due to loss of appetite.

Probenecid is not designed to treat acute gout episodes. Rather, it is a preventive drug that reduces the chances of such attacks occurring. If a person does experience a painful gout episode during treatment with probenecid, he or she should speak to a doctor about taking a different short-course medication to ease temporary symptoms.

WiseGEEK is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.