We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Ganglioneuroblastoma?

By Jillian O Keeffe
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

A ganglioneuroblastoma is a type of cancer that grows out of the nerves of the body. Normally affecting children, the tumor is very rare, and usually presents itself as a growth somewhere on the body. Possible treatments include surgical removal of the tumor, drug or radiation therapies, and although ganglioneuroblastoma can be fatal, it tends to be less aggressive than some other types of cancer.

When a child develops in the womb, cells called neuroblasts are the original cells from which nerve cells develop. Ganglion cells are types of nerve cells that are commonly found in the spine. A ganglioneuroblastoma, therefore, is a tumor that generally involves both neuroblast and ganglion cells. Doctors can actually separate a ganglioneuroblastoma into several varieties, depending on how much of the tumor is made up of either type of cell.

Tumors with one or more significant lumps of neuroblasts together with ganglion cell growth are called nodular ganglioneuroblastomas, whereas more scattered, and less obvious neuroblast groups with ganglions are classified as intermixed ganglioneuroblastomas. A maturing ganglioneuroblastoma is one with no neuroblasts and ganglions that are still growing, whereas a tumor made up entirely of mature ganglion cells is referred to as a mature ganglioneuroblastoma. Cancers that involve ganglions tend to spread less rapidly than those that contain only neuroblasts, so the tumor falls into a group of cancers that are called "intermediate" in terms of aggressiveness.

Normally, the first signs of a ganglioneuroblastoma involve the appearance of a lump on the child's body. Most commonly, the lump originates in the abdominal area. As the condition only affects about five out of 1,000,000 children, a doctor typically has to order a variety of tests to figure out the cause of the lump. These tests include medical scans such as magnetic resonance imaging (MRI) or a computer tomography (CT) scan. The child also usually has to give blood and urine samples, and a more invasive and uncomfortable bone marrow sample may also be required.

If the scans and tests indicate the presence of a tumor, the child generally also has to undergo a biopsy so it can be confirmed through microscopic analysis. Surgery to remove it is a common option, and drugs and radiation to help kill the cancer cells are also available for this type of cancer. Children whose tumors have not yet spread have the best chance of a good outcome.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
By anon968429 — On Sep 03, 2014

I am not sure four sentences of information can provide enough information for a reliable diagnosis, and no one has a date stamped on the bottom of there foot. Pray for your friend. Miracles happen every day.

By anon313616 — On Jan 13, 2013

My friend was just diagnosed with GNB. His case is very odd. He had a seizure which then resulted in him having an MRI and C-Scan and they found a tumor in the frontal lobe, on the right hemisphere. I don't remember exactly where, but I think it is near Broca's area. They removed the tumor and they did a biopsy and then they told him he had GNB at a stage 4 and told him he had about a year and a half to live. Are they right?

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.