What is a Drug Interaction?

Margo Upson

A drug interaction occurs when a drug interferes in a negative way with another drug or medical condition. These interactions can occur between two drugs, by combining medications with particular foods or drinks, or by a drug interfering with another medical condition. It does not only happen with prescription drugs, it can happen with over the counter medications, vitamins and supplements, and illegal substances.

Negative drug interactions include overdosing.
Negative drug interactions include overdosing.

Every medication is designed to create a certain effect in the body. Drug interactions typically occur when the intentions of one drug interferes with the intentions of the other. For example, antacids coat the stomach, making it harder for other drugs to get into a person's system. Drugs can also interact with a medical condition. Blood thinners help to prevent clotting, heart attacks, and strokes, and are often prescribed to individuals with certain heart conditions. If someone has weak blood vessel walls, or if they bruise easily, then blood thinners can cause a bleeding disorder.

When a pharmacist clearly understands what is being prescribed, he can help prevent drug interactions.
When a pharmacist clearly understands what is being prescribed, he can help prevent drug interactions.

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Medications can also interact with illegal drugs or with alcohol. Most prescription medications are not supposed to be taken with alcohol, as alcohol can alter the way the medication acts. Vitamins, herbal remedies, or supplements can also negatively interact with other medications. Many people do not realize that different herbs, even ones found in teas, can interfere with their medications.

Headaches are a common symptom of a drug interaction.
Headaches are a common symptom of a drug interaction.

The most common symptoms of a drug interaction are headaches, nausea, dizziness and fatigue. It can also cause heartburn or a change in blood pressure. In some cases, drug interactions can lead to constipation or diarrhea, muscle weakness, tremors, anxiety, or clumsiness. In extreme cases, drug interactions can lead to severe medical problems or even death.

Drug interactions can occur with prescription medications, as well as over-the-counter supplements.
Drug interactions can occur with prescription medications, as well as over-the-counter supplements.

Many complications due to a drug interaction are preventable. When you visit your doctor, bring a list of any medications you are currently taking, even if you only take them occasionally. Check with your doctor or pharmacist before beginning any new treatment, even for over the counter medications. Have one pharmacy that your entire family uses, so that the pharmacist has an accurate record of any medications you may be on. Many pharmacies automatically check your files to look for any potential interactions.

If an individual bruises easily, then blood thinners could cause a bleeding disorder.
If an individual bruises easily, then blood thinners could cause a bleeding disorder.

Be sure to read the labels on any medication very carefully before you begin treatment, and take only the recommended dosage. There are many websites and books that can help you check for any potential drug interactions. If you are experiencing the symptoms of a drug interaction, call your doctor or head to the nearest hospital, especially if the symptoms are severe. Remember that a drug interaction can be deadly; immediate treatment may mean the difference between life or death.

Drugs can sometimes interfere with other drugs or cause negative reactions in combination with existing health conditions.
Drugs can sometimes interfere with other drugs or cause negative reactions in combination with existing health conditions.

Discussion Comments

wizup

@goldensky - Lipitor should not be taken with any form of grapefruit. Grapefruit blocks the enzymes in the small intestine that breaks down medications causing the drug level to increase in your blood stream. There’s a drug interactions checker at drugs.com that explains this in more detail.

The thing about grapefruit is that it stays in your system for awhile, anywhere from 24 hours to 3 days. So I would stop eating the fruit altogether while taking lipitor. Otherwise it may increase your risk of causing serious muscle and organ damage.

You really should talk to your doctor about it. Maybe he/she could prescribe something that grapefruit has no effect on.

goldensky

My doctor just prescribed me with lipitor to help reduce my cholesterol. I’ve been hearing a lot of talk lately about grapefruit interactions on certain drugs. Is lipitor one of them?

If so, is it still okay to eat the fruit itself? Can I eat it at a different time of the day than when I’m taking my medicine? Grapefruit juice has so many nutritional values that I didn’t think to tell my doctor that I drink it or that it would even be a problem.

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