What are Herb-Drug Interactions?

Tricia Christensen
Tricia Christensen
St. John's wort, which can interact with MAOIs.
St. John's wort, which can interact with MAOIs.

Herb-drug interactions are generally adverse reactions that occur when people combine certain herbal medicines with more traditional prescribed or over the counter medicines. This potentially dangerous practice is frequently overlooked by people who take herbs because they see these as benign replacements to “prescribed” and chemically-oriented drugs. Such a point of view is particularly dangerous, especially with certain herb-drug interactions, and anybody who takes more than one drug, be it chemical or herbal in nature, should not be complacent. Talking with a pharmacist or a doctor prescribing medicine is the best way to determine no dangerous interactions occur.

Mixing herbal medications with prescription drugs can be dangerous.
Mixing herbal medications with prescription drugs can be dangerous.

Sometimes herb-drug interactions have a synergistic effect, which means they work together to enhance the action of at least one of the medicines. This is especially true when herbs and drugs used are for the same basic purpose. Taking herbs like kava kava or valerian is common to treat anxiety.

It is not advisable to, at the same, time take prescription drugs that have the same effect. Blending valerian and Xanax®, for example, might create a much higher level of sedation. Even adding an over the counter antihistamine like diphenhydramine (Bendaryl®) may suppress the respiratory system to a certain degree or cause extreme drowsiness. Amounts taken may greatly increase herb-drug interactions and be highly dangerous.

Ginko appears to have possible side effects such as blood thinning and preventing blood from clotting.
Ginko appears to have possible side effects such as blood thinning and preventing blood from clotting.

One drug that interacts with many herbs is warfarin (Coumadin®). It also interacts with numerous other prescription drugs and foods. People need to be very cautions before using any type of herbs with warfarin, and especially any type of herbal preparations that may have a blood-thinning effect. An herb like feverfew, which is often used for strong headaches or for its anticoagulant effect is absolutely contraindicated if a person takes warfarin or other blood thinners like aspirin. Other herbs such ginkgo biloba, licorice, garlic and ginseng, may either increase blood thinning or decrease the efficacy of warfarin and are not advised.

Speaking with a prescribing doctor can help a patient ensure that no herb-drug interactions occur.
Speaking with a prescribing doctor can help a patient ensure that no herb-drug interactions occur.

Another example of how herb-drug interactions can be dangerous occurs when people use herbal and prescribed antidepressants concurrently. St. John’s Wort, bears strong relationship to a group of antidepressants called monoamine oxidase inhibitors (MAOIs). People should never double up on herbal and prescribed MAOIs, as this may cause extreme illness. Additionally, using St. John’s Wort is contraindicated for people using oral birth control because it may lower protection from unwanted pregnancy: a very serious consideration.

What herb-drug interactions truly say is that herbs have to be respected as real medicine. Unfortunately they are not given the same kind of scrutiny in many countries as are prescription drugs, and people may view them as somehow less potent or less capable of both healing and damage as chemically produced drugs. It might be more useful to understand that herbs and drugs really are all drugs, and safely using them means getting medical assistance when deciding which of these drugs are combined without ill effects.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

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    • St. John's wort, which can interact with MAOIs.
      By: M. Schuppich
      St. John's wort, which can interact with MAOIs.
    • Mixing herbal medications with prescription drugs can be dangerous.
      By: Evgenia
      Mixing herbal medications with prescription drugs can be dangerous.
    • Ginko appears to have possible side effects such as blood thinning and preventing blood from clotting.
      By: evgenyb
      Ginko appears to have possible side effects such as blood thinning and preventing blood from clotting.
    • Speaking with a prescribing doctor can help a patient ensure that no herb-drug interactions occur.
      By: 18percentgrey
      Speaking with a prescribing doctor can help a patient ensure that no herb-drug interactions occur.