We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What are Nolvadex® Side Effects?

Tricia Christensen
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Nolvadex®, also called tamoxifen, is an oral drug that is used as part of a treatment or prevention regimen of breast cancer or reproductive tract cancers of certain types and stages. It reduces estrogens in the body, which can produce a number of side effects, most of them similar to menopausal side effects. For many women and the few men who use this drug, Nolvadex® side effects are minor enough that they do not require discontinuation of the drug. Nevertheless, anyone taking this medicine must watch for more severe reactions and be aware of tamoxifen contraindications to prevent problems.

Some of the most common Nolvadex® side effects are similar to those experienced by women undergoing menopause. The most frequently reported effect is flushing and hot flashes, which may occur in about 30-60% of drug users. Cessation of, or changes to monthly periods are fairly common, and about 10-20% of women will note this. Other side effects occur in decreasing frequency, and include symptoms like bone or joint pain, nausea, fluid retention, development of cysts on the ovaries, changes in mood — particularly depression — and poor appetite.

Men clearly experience some different Nolvadex® side effects and may be most affected sexually with a reduced libido. Other more serious side effects for both women and men are rarer. Some of these are vomiting, hypertension, increased risk for cardiac events and stroke, bone mass loss (osteoporosis), hemorrhage, rash, anemia, and headaches. It’s important to recall that these side effects aren’t expected in all people who take this medicine, and some side effects may be managed by using other medications concurrently.

The most severe adverse effects are usually those associated with developing osteoporosis, having a stroke, or the medicine causing rare forms of cancer. Instances of these are rare but are recorded, and they’re worth understanding as part of the risk of taking the tamoxifen. Some of the Nolvadex® side effects contraindicate it for use with some people.

Pregnant women cannot take tamoxifen because it may have toxic effects on the fetus. Those who have a history of stroke or deep vein thrombosis are also advised against using this medication. People who use blood thinners, especially warfarin, are at additional risk for bleeding disorders if Nolvadex® is used. Patients should present a complete list of medical conditions, histories and any medications presently taken, with any known medication sensitivities to physicians, prior to accepting this drug.

Given the small but real potential of Nolvadex® side effects to be extremely severe, patients usually require careful monitoring when on this medication. This will mean regular check-ups with the prescribing physician, and patients should report any side effects they experience at these times. Physicians will usually order regular blood tests and scans to make sure the medicine is effective and is not causing adverse effects.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Tricia Christensen
By Tricia Christensen , Writer
With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia Christensen is based in Northern California and brings a wealth of knowledge and passion to her writing. Her wide-ranging interests include reading, writing, medicine, art, film, history, politics, ethics, and religion, all of which she incorporates into her informative articles. Tricia is currently working on her first novel.

Discussion Comments

Tricia Christensen

Tricia Christensen


With a Literature degree from Sonoma State University and years of experience as a WiseGeek contributor, Tricia...
Learn more
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.