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What Should I Know About Statins and Grapefruit?

Lainie Petersen
Updated May 17, 2024
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If you take statin drugs for lowering cholesterol, it is a good idea to avoid grapefruit and grapefruit products. Statins and grapefruit don't mix because components in grapefruit interfere with the way statins are broken down in the body. If the body can't properly metabolize cholesterol-lowering drugs, the drugs can build up in the patient's system, resulting in an overdose. Side effects of an interaction between statins and grapefruit include potentially fatal liver, kidney, and muscle damage.

Grapefruit is a healthy food that is low in calories and high in vitamin C, antioxidants, and potassium. It is understandable that those who take statin drugs might want to add fresh grapefruit or grapefruit juice to their diets. Unfortunately, a compound in grapefruit known as bergamottin interferes with the enzymes needed to metabolize certain statin drugs, including atorvastatin (Lipitor®), simvastatin (Zocor®), and lovastatin (Mevacor®). Evidence shows that only one instance of grapefruit or grapefruit product consumption can be enough to cause these drugs to build up in your system, and timing doesn't matter much either. Even if you eat or drink grapefruit products many hours after taking your pills, the risk is still present.

Statins and grapefruit are not the only significant drug/fruit interaction of which you need to be aware. Both pomelos and Seville oranges can have a similar effect. Seville oranges are often included in fruit compotes and marmalades, and pomelos, or Chinese grapefruit, are a citrus fruit from southeast Asia that can be found in ethnic markets. The problem of toxic drug buildup similar to that caused by the interaction of statins and grapefruit can occur when people mix other drugs with fruits that contain bergamottin. These drugs include some antidepressants; calcium channel blockers; and cardiac, HIV, and anti-seizure medications.

Fortunately, people who take statin drugs may not need to abstain from grapefruit or its juice forever. The metabolism of some cholesterol drugs, such as pravastatin (Pravachol ®), fluvastatin (Lescol ®), and pitavastatin (Livalo ®), doesn't seem to be affected by grapefruit in the same way as other statin drugs. Still, some medical professionals advise caution when combining the two anyway, and suggest that patients delay grapefruit consumption for several hours after taking their medication. If you enjoy eating grapefruit, be sure to talk with your doctor or pharmacist about potential interactions with your medications. It may be possible to switch to an alternative drug or lower your dosage so that you don't have to worry about the interaction between statins and grapefruit.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Lainie Petersen
By Lainie Petersen
Lainie Petersen, a talented writer, copywriter, and content creator, brings her diverse skill set to her role as an editor. With a unique educational background, she crafts engaging content and hosts podcasts and radio shows, showcasing her versatility as a media and communication professional. Her ability to understand and connect with audiences makes her a valuable asset to any media organization.
Discussion Comments
By Perdido — On Dec 20, 2012

I take a calcium channel blocker for my high blood pressure, and I have to avoid grapefruit. However, this is no problem for me. I hate the bitter taste of the fruit, so there is no danger of me forgetting about the interaction and eating it anyway.

By monib — On May 04, 2011

How about mixing pravastatin and vitamin C supplement?

Lainie Petersen
Lainie Petersen
Lainie Petersen, a talented writer, copywriter, and content creator, brings her diverse skill set to her role as an...
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