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What is Zomig®?

By Jacquelyn Gilchrist
Updated May 17, 2024
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Zomig® is a brand name for the generic medication zolmitriptan. It is a prescription-strength migraine drug that may help relieve common symptoms, such as throbbing headache, upset stomach, and sensitivity to light and sound. Zomig® is classified as a selective serotonin (5-HT) receptor agonist, which works to reduce swelling of blood vessels, particularly the ones around the brain, as well as block the release of substances that cause painful or bothersome symptoms.

Patients cannot take Zomig® to prevent a migraine, but only to improve symptoms after they have already begun. This drug is available in a regular tablet or a tablet intended to dissolve in the mouth. The regular tablet may be taken with a glass of water, with or without food. Disintegrating tablets should be placed on the tongue and left there until it is completely dissolved. It should not be chewed, however the dissolved residue may be swallowed with a glass of water.

No more than 10 milligrams (mg) of Zomig® may be taken in a 24-hour period, however the doctor will provide individualized dosage instructions for each patient. Typically, the person will take a tablet when he experiences migraine symptoms. When symptoms are alleviated, but then return, the patient may take a second tablet no sooner than two hours following the first dose. A second dose should not be taken if symptoms were not alleviated with the first dose. Instead, patients should contact their doctors for further instruction.

Zomig® may result in some side effects. Patients may notice an upset stomach, dry mouth, and flushing or feeling of warmth. General weakness and drowsiness may also occur. Some people have noticed a sensation of pressure or pain in the throat. The doctor should be notified if these effects become bothersome.

Serious side effects from the use of Zomig® require emergency medical care. These can include chest pain, pain that spreads to the shoulder or arm, and sudden numbness or weakness. Nausea, malaise, and problems with balance, speech, or vision have been reported. Some people may experience a rapid heartbeat, dizziness, and bloody diarrhea. Hallucinations, high fever, and overactive reflexes may also occur, especially if Zomig® is taken with an antidepressant.

Before taking Zomig®, patients should discuss their other medications and supplements with their physicians. It may interact with acetaminophen, birth control pills, and antidepressants. Other medical conditions must also be disclosed, such as liver disease, coronary artery disease, and high blood pressure. It is unknown whether this drug will harm an unborn or nursing infant.

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