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What is Triprolidine?

K.C. Bruning
Updated May 17, 2024
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Triprolidine is an over-the-counter antihistamine drug. It is primarily recommended for patients who suffer from seasonal allergies. Some doctors also prescribe it to be taken with certain cold medications in order to treat flu symptoms. It is marketed under the product names Actidil® and Myidil®.

The drug is most often used to treat symptoms such as sneezing, runny nose, and itching and watery eyes that are primarily caused by environmental allergies. It works by lowering the level of a naturally-occurring chemical in the body called histamine, which triggers the reaction that leads to allergy symptoms. Triprolidine contains an anticholinergic agent, which is a substance that impedes the process that leads to the production of histamine.

Doctors usually recommend that triprolidine be taken for a short period of time until symptoms go away. It comes in liquid form, and is best taken with food in order to avoid upset stomach. The drug is expected to take full effect within seven days. Patients are usually advised to consult a doctor if they do not see an improvement in symptoms by the end of a week of taking the drug.

Some previous conditions may require that the doctor adjust the recommended dosage of triprolidene or at least observe the patient more closely while undergoing treatment. Any past or current experience with kidney disease, glaucoma, difficulties urinating, or an enlarged prostate should be disclosed to a doctor. Women who are pregnant, plan to become pregnant, or who are nursing should also speak to a doctor as they are generally advised not to take the drug.

The mild side effects of triprolidine should be discussed with a doctor, though it is not necessary to stop taking the medication should they appear. Many patients will experience drowsiness after taking the drug. Other possible symptoms include nausea, stomachache, diarrhea, or constipation. Patients may also experience blurred vision, dizziness, and drowsiness. Some individuals have trouble concentrating or suffer lapses in memory while taking the drug.

More serious side of effects of triprolidine include severe restlessness, nervousness, anxiety, or dizziness. Some patients may also experience a pounding heart, fainting, or feel light-headed. Other severe effects include unusual behavior or thoughts, confusion, and hallucinations. A doctor should be consulted as soon as possible if any of these symptoms appear as a result of taking the drug. Any signs of an allergic reaction, including swelling of the tongue, face, lips, or throat; difficulty breathing; and hives should receive emergency medical attention.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
K.C. Bruning
By K.C. Bruning , Former Writer
Kendahl Cruver Bruning, a versatile writer and editor, creates engaging content for a wide range of publications and platforms, including WiseGeek. With a degree in English, she crafts compelling blog posts, web copy, resumes, and articles that resonate with readers. Bruning also showcases her passion for writing and learning through her own review site and podcast, offering unique perspectives on various topics.

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K.C. Bruning

K.C. Bruning

Former Writer

Kendahl Cruver Bruning, a versatile writer and editor, creates engaging content for a wide range of publications and...
Learn more
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