We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is the Urothelium?

By Eric Stolze
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

The urothelium is the bladder’s lining that also coats other parts of the urinary system, including the ureters. In most cases, people have two ureters—one tube that links the left kidney to the bladder and another that links the right kidney to the bladder. Urothelial cancer is a medical condition that can strike the urothelium. Bladder cancer is the most common form of urothelial cancer.

People with bladder cancer typically develop malignant tumors in the urothelial cells of the bladder wall. Three forms of cancer can develop in the bladder’s urothelium: transitional cell carcinoma, adenocarcinoma and squamous cell carcinoma. Transitional cell carcinomas usually develop in the innermost urothelium layer of the bladder wall, and this type of tumor may be flexible enough to stretch as the bladder empties or fills with urine. In many cases, an adenocarcinoma grows in glandular cells of the bladder’s urothelium that typically create mucous. Squamous cell carcinomas may develop in flat and thin squamous cells of the urothelium after irritation or an infection.

Urothelial cancer of the bladder is generally more likely to occur in people over 60 years of age. Men, tobacco users and individuals with a personal history of bladder infections may be at a greater risk of developing bladder cancer. Individuals who used a urinary catheter for a long period of time, people who underwent a kidney transplant and patients who were exposed to high levels of arsenic in their drinking water may also be more likely to get urothelial cancer of the bladder. Exposure to some industrial chemicals, such as those used in the production of dyes, textiles and rubber, can increase a person’s susceptibility to bladder cancer in some cases.

Doctors may use a thin tube with a light called a cystoscope to look through the urethra into the bladder and identify signs of cancer in the urothelium. Some physicians also use blood and urine tests to find signs of cancer. Patients with bladder cancer may experience frequent urination and may not being able to urinate when they feel bladder pressure. Bloody urine, lower back pain and pain during urination have been reported by some patients with urothelial cancer of the bladder.

Cancer of the bladder’s urothelium may be treated with several forms of cancer therapy, including surgical removal of a cancer tumor. Some surgeons use a cystoscope to burn away or remove a cancer tumor. Advanced bladder cancer cases may be treated with partial or total surgical removal of the bladder. Surgeons typically create a new means for urine to be expelled from a patient’s body after the entire bladder has been removed. Other treatments for urothelial cancer of the bladder may include chemotherapy or radiation therapy that kills cancer tumor cells.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.