We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Rosiglitazone?

By Helga George
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Rosiglitazone is an anti-diabetic drug that in the chemical class of thiazolidinediones. This compound is effective at restoring cells' ability to respond to insulin for people with Type II diabetes. The drug can be taken alone, often sold under the name Avandia®, or can be taken in combination with metformin or sulfonylureas. Rosiglitazone has been the subject of controversy, since there is evidence that it can lead to heart attacks. A panel of the United States Food and Drug Administration (FDA) considered whether to take the drug off the market in 2010, but decided it was valuable enough to allow it to be continued to be sold under tight restrictions.

There are two anti-diabetic drugs in the thiazolidinedione class. In addition to rosiglitazone, there is pioglitazone, also known as Actos®. The mode of action for drugs in this class is to make cells more sensitive to insulin. This results in a reduction in the concentration of sugar, insulin, and fatty acids in the blood.

These drugs cause these changes by activating receptors on the membranes of the cell's nucleus. The nucleus is the location of the cell where most of the DNA is stored. Receptors are molecular switches that signal events to happen when a particular compound binds to them.

Peroxisomes are cellular structures in which much of the body's fatty acid metabolism takes place. In this case, rosiglitazone binds to a particular subtype of receptor called a peroxisome proliferator-activated receptor (PPAR), of which there are many different types. The binding of this drug to a particular PPAR activates it to express DNA that regulates genes involved in fat cell development, fatty acid metabolism, and the uptake of blood sugar.

These changes take effect in fat, muscle, and liver tissues. With a decreased sensitivity to insulin, these tissues function more effectively. These changes help to control Type II diabetes. The thiazolidinediones are meant to be used in conjunction with lifestyle changes, such as modifying one’s diet and getting more exercise.

As rosiglitazone became a commonly used drug, studies appeared linking the drug to an increased frequency of heart attacks. A number of lawsuits were placed against the manufacturer, although many were settled. In 2010, the FDA held several meetings to consider putting restrictions on the drug, first putting a black box warning on the drug's packaging warning of potential heart problems. In September 2010, the FDA and European drug regulators decided that the drug could no longer be sold in Europe, and that sales in the US would be limited only to patients who have had no success using other medicines.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.