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What Is Phenindione?

By Meshell Powell
Updated May 17, 2024
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Phenindione is a type of prescription medication known as an anticoagulant and is used to prevent or treat blood clots. This drug is available in the form of an oral tablet and should be used exactly as prescribed by the supervising physician. Some of the possible side effects of phenindione include sore throat, diarrhea, and fever. More serious side effects of this medication may include abnormal bleeding or damage involving the kidneys or liver. Specific questions or concerns involving the use of phenindione in an individual situation should be discussed with a doctor or other member of the medical staff.

Blood clots occur when cells known as platelets join together and form masses known as clots. These clots can interfere with the normal circulation of blood and may sometimes travel through the bloodstream to vital organs such as the lungs. Without proper treatment, blood clots can cause serious health complications or even death. Phenindione is often prescribed to prevent these clots from forming or to help dissolve them after they develop.

Most people are able to take phenindione without experiencing significant side effects, although any new or bothersome symptoms that develop after beginning treatment with this medication should be reported to a doctor for further evaluation. Gastrointestinal disturbances such as nausea, diarrhea, or vomiting are common and may occasionally need to be treated with additional medications. Some people who take this drug may also experience flu-like symptoms such as sore throat, fever, or muscle aches.

Less frequent side effects of phenindione may involve abnormal or excessive bleeding and damage to vital organs such as the liver or kidneys. A significant amount of bruising or bleeding should be reported to a doctor right away, as the dosage may need to be changed. In severe situations, a blood transfusion or surgical intervention may become necessary. Blood in the urine or a decrease in the amount of urine produced may indicate kidney damage, sometimes requiring dialysis or transplant. Jaundice is a medical condition that often occurs when the liver is no longer able to function properly and is characterized by yellowing of the skin and eyes.

Rarely, phenindione can cause allergic reactions, even if the medication has been taken successfully in the past. Minor allergic reactions may consist of itching or the development of a skin rash. A more severe and potentially life-threatening type of allergic reaction known as anaphylaxis can cause difficulty breathing and swelling of the throat or tongue. This drug may also interfere with the effectiveness of some medications, so any concerns should be discussed with the prescribing physician.

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