What Is Paclitaxel and Carboplatin Chemotherapy?

Paclitaxel and carboplatin are two chemotherapy drugs administered together to treat patients with cancer. A doctor will most often prescribe this anti-cancer regimen for those with ovarian cancer; however, it may also treat lung cancer and other types of cancer. These medicines work by attacking the abnormal, cancerous cells, but in the process, healthy cells are also destroyed. This causes side effects and potential complications that the patient should discuss with his doctor before undergoing treatment.

Prior to administering paclitaxel and carboplatin chemotherapy, the doctor will order a blood test to ensure that the blood count is high enough for the patient to receive the drugs. Patients must also take other medicines to prevent an allergic reaction to paclitaxel. They may take these either orally or via an injection at the hospital.

A doctor will insert a thin tube into a vein in the patient's arm to administer the paclitaxel and carboplatin drugs. Paclitaxel is transferred into the body over the course of about three hours. This is followed by a dose of carboplatin, which generally takes about one hour. Some patients may be able to return home following their chemotherapy session, while others may need to remain in the hospital overnight. Usually, the doctor will prescribe a dosage once every three weeks, typically for a total of five to six months.

Some side effects are likely to occur as a result of chemotherapy, which the patient should report to the doctor if they become severe. Nausea and vomiting are common, and may be prevented or relieved by anti-nausea drugs. Other possible side effects include fatigue, joint and muscle pain, and diarrhea. A sore mouth or mouth ulcers, hair loss, and unexplained bruising or bleeding may also occur. Since chemotherapy lowers the white blood cell count, patients are more susceptible to infections, which may be indicated by a fever.

Paclitaxel and carboplatin may also cause abdominal pain, headaches, and changes in hearing or the sense of taste. Some patients may have a temporarily slowed heartbeat or impaired kidney function. Other complications that may result from chemotherapy may include blood clots, infertility, and irregular or missed menstrual periods.

Before undergoing paclitaxel and carboplatin chemotherapy, patients must disclose all of their other medical conditions, including whether they are breastfeeding, pregnant, or may become pregnant. They should also tell their doctors about all other medications and supplements they take, including over-the-counter drugs. Certain precautions should be taken while receiving this treatment. Patients should avoid receiving live vaccinations or coming into contact with anyone with a contagious illness.