We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Factor IX?

By Jillian O Keeffe
Updated May 17, 2024
Our promise to you
WiseGEEK is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGEEK, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Factor IX is a molecule that plays a role in the blood clotting system. When a person loses blood from a cut, the body sets a special system in action. This involves different molecules signaling to each other, telling other substances to block up the source of bleeding and prevent further blood loss. People without efficient Factor IX cannot produce normal clots, and so can suffer from uncontrolled bleeding.

Blood clotting happens because many different molecules and cells work together to coagulate, or clot, the free-flowing blood at the affected site. Many of the molecules that act in this system are known as blood clotting factors, and Factor IX is just one of them. This is an enzyme, which means that it helps reactions to take place, and also helps substances to become modified into other substances.

The origin of Factor IX is in the cells of the liver. Here the molecule is produced in an early form and other molecules and enzymes, such as Vitamin K, act on it to alter it into a form suitable to circulate in blood. After the liver sends the Factor IX out into the blood, the molecule has a half-life of about one day, which means that half of new Factor IXs degrade within 24 hours.

Only when a person begins to bleed does the blood clotting process begin. Signals from the body activate other factors in the system, which in turn activate Factor IX. The exact molecules that turn the factor on are activated Factor VII and Factor XI. When these molecules work on Factor IX to tell it to begin its own work in the process, the result is that Factor IX then turns on the activity of another factor called Factor X.

All of these factors are essential to normal blood clotting, and the absence of one factor means that the body does not properly stop bleeding. The gene that codes for this particular factor is on the X chromosome, which helps to dictate gender. Women have two X chromosomes, and men have one X and one Y.

When a mutated form of the gene is present on a chromosome, it can cause a condition called Hemophilia B. Usually, one normal gene can make up for a mutated gene, which is the reason why men suffer from the disease and women usually do not. Treatment for the disorder requires that the person take artificial preparation of the factor, in order to replace the missing substance and prevent risks from uncontrolled bleeding.

WiseGEEK is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.