We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Ezetimibe Simvastatin?

Mary McMahon
By
Updated May 17, 2024
Our promise to you
WiseGEEK is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGEEK, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Ezetimibe simvastatin is a combination of two drugs available for the treatment of high cholesterol. It is known under brand names like Zetia® and a doctor may prescribe it if a patient fails to respond to a single drug regimen for cholesterol management. Along with taking medication, a patient may need to make diet and lifestyle changes to control cholesterol levels adequately. These can include increasing frequency of exercise and eliminating or cutting back on foods known to increase cholesterol.

The ezetimibe works by blocking absorption of cholesterol from the small intestine, limiting the amount of dietary cholesterol the patient ingests. Simvastatin, a statin medication, reduces production of cholesterol in the liver by blocking the function of key enzymes. This combination therapy attacks blood cholesterol from two different angles, by limiting the amount available to work with in the first place and preventing the body from producing it.

Patients on ezetimibe simvastatin can experience a variety of side effects. Nausea, loose stool, and headaches are not uncommon. Some patients develop fatigue and muscle pain. This medication can cause a rare and dangerous side effect, rhabdomyolysis, where the body starts to break down its own muscle tissue. This can cause acute pain, usually starting in the extremities, and will rapidly overload the kidneys with protein, potentially causing serious complications. People who experience sharp, persistent pain while taking ezetimibe simvastatin should discuss it with their doctors.

These drugs can interact negatively with some other medications, including certain antibiotics and anticoagulant medications. Before taking any new medication, it is advisable to go over all drugs being taken, including over-the-counter drugs, with a doctor. The doctor can identify any potential conflicts and adjust the patient's drug regimen to avoid bad drug reactions. Drinking large amounts of grapefruit juice while on ezetimibe simvastatin can also be dangerous, as it can interfere with how the body absorbs and breaks down the medication, and can result in elevated levels of the medication in the blood.

The efficacy of this medication has been the subject of several studies. Some researchers claim ezetimibe simvastatin is no more effective than simvastatin alone. Patients considering this medication should discuss all their treatment options with a doctor and get information about the latest research on cholesterol and medications used to manage it. Relying on the medication alone may not be enough to bring the patient's cholesterol down to a safe level, and it is also important to give the medication time to work. It may take weeks or months for the patient's cholesterol levels to fall and stabilize at new concentrations.

WiseGEEK is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Mary McMahon
By Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a WiseGEEK researcher and writer. Mary has a liberal arts degree from Goddard College and spends her free time reading, cooking, and exploring the great outdoors.

Discussion Comments

Mary McMahon

Mary McMahon

Ever since she began contributing to the site several years ago, Mary has embraced the exciting challenge of being a...

Learn more
WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGEEK, in your inbox

Our latest articles, guides, and more, delivered daily.