What Is Drospirenone and Estradiol?

Drospirenone and estradiol is a combination hormone replacement therapy (HRT) that provides a menopausal woman with synthetic estrogen, because she is unable to make enough of the hormone naturally. Drospirenone, which is a synthetic form of the hormone progestin, helps to moderate the possible complications that estradiol may cause. This pill may be prescribed to women who suffer from symptoms of menopause, such as dizziness, faintness, and hot flashes, as well as unusual sweating and vaginal discomfort. It is only intended for use by women who have not had a hysterectomy to remove the uterus. This medicine may also help lower the risk of osteoporosis, which is the loss of bone mass.

The prescribing physician should discuss the risk of serious health complications. Hormone replacement therapy may increase a woman's risk of suffering from a stroke, heart disease, or blood clots, such as deep vein thrombosis. Drospirenone and estradiol may also elevate the risk of cancer of the breast or ovaries. These hormones are best used for the shortest amount of time possible.

A patient will typically be prescribed one tablet once daily, which may contain 1 milligram (mg) of estradiol and 0.5 mg of drospirenone. It is taken by mouth with a full glass of water. Patients should take it at the same time each day.

Some side effects may occur with the use of drospirenone and estradiol, which should be reported to the prescribing physician if they become severe. Patients may experience nausea, an upset stomach, and bloating. Dizziness and irritability can occur, along with a headache. Some women have noticed a change in vaginal discharge, a change in libido, or tenderness of the breast. Weight gain or loss has also been reported.

More serious side effects require immediate medical care. These can rarely include trouble breathing, confusion, or sudden vision changes. Fainting, weakness on one side of the body, and swelling of the arms or legs have also been reported. Some women may rarely experience jaundice, unusual vaginal bleeding, and mood changes. Lumps in the breast and nipple discharge have also occurred.

Before using drospirenone and estradiol to treat symptoms of menopause, patients must disclose their other medical conditions, medications, and supplements. Women who are pregnant or breastfeeding should not use this hormone replacement therapy. It may be contraindicated for use by those who have diabetes, kidney disease, or heart problems. Drospirenone and estradiol may interact with other drugs, including diuretics, aspirin, and potassium supplements.