We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Cycloserine?

By Maggie J. Hall
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Cycloserine is an antibiotic that physicians may prescribe for the treatment of lung or systemic tuberculosis. Other uses of cycloserine include the treatment of certain urinary tract infections. As the drug is not typically as potent as conventional tuberculosis antibiotics, pharmacological studies suggest using the medication in conjunction with similar medications. Patients generally require routine blood tests to monitor the level of the drug in the bloodstream because of the potential risk of serious central nervous system side effects.

The antibiotic originates from the bacterial strain Streptomyces orchidaceus, discovered during the fermentation brewing process in the 1950s. Pharmaceutical companies either use the bacteria to produce cycloserine or manufacture the medication synthetically. The medication proved effective in fighting Mycobacterium tuberculosis, and researchers discovered that it also successfully treats infections caused by susceptible gram-negative and gram-positive bacteria, which includes the Enterobacter genus and Escherichia coli.

The drug helps to eliminate susceptible bacteria by preventing the organisms from producing a protective outer cellular membrane. Physicians usually require sputum or urine culture and sensitivity tests before prescribing cycloserine. The recommended cycloserine dose begins at 250 milligrams, which patients take in oral capsule form every 12 hours. Dosages must not exceed a total of 1 gram per day. Studies indicate taking the medication with a meal containing fatty foods reduces the drug's absorption by up to one half.

The kidneys eliminate the majority of the medication from the body, and pharmaceutical companies do not recommend the medication for patients with renal impairment. The drug may also reduce levels of vitamin B12 and folic acid in the body when taken with other anti-tubercular medications, and vitamin supplementation may be required. A combination of cycloserine and similar antibiotics may also affect red blood cell production by creating abnormally shaped and sized cells.

Side effects of cycloserine include dizziness, drowsiness, headaches, and joint pain, and some patients develop skin rashes. Patients should exercise caution and not operate motorized equipment or vehicles if experiencing alterations in cognition or consciousness. Patients taking more than 500-milligram per day may experience serious central nervous system reactions that include confusion, convulsions, or personality changes, in the form of aggressive or irritable behavior. These individuals might also suffer tremors or seizures.

Patients who experience serious reactions may require a dosage reduction or adjunctive treatment with antidepressant or anti-seizure medications. As the medication can produce a variety of central nervous system adverse effects, studies advise against prescribing the antibiotic for patients with epilepsy. Cycloserine interactions include alcoholic, as the combination can produce epileptic events. Taking the antibiotic with ethionamide or isozianid may increase the risk of serious neurological effects.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.