What is Cancer Immunotherapy?

J. Leach
J. Leach
Vaccines can help improve a body's response to chemotherapy.
Vaccines can help improve a body's response to chemotherapy.

Cancer immunotherapy uses the patient's immune system to combat cancer. This is achieved in two different ways: active and passive treatments. Active therapy seeks to stimulate the patient's immune to system to attack the cancer, usually accomplished through vaccines. Passive cancer immunotherapy does not rely upon the body to respond to the cancer, but offers man made tools to the body to fight the disease. These tools are usually antibodies.

People with weakened immune systems are more susceptible to cancer. This is not to say that someone with a healthy immune system cannot succumb to cancer, but the incidence is much higher if one's health is seriously compromised. Cancer immunotherapy attempts to give the patient's immune system the tools or training, as is the case with vaccines, to battle cancer.

Many tumors produce antigens. Antigens are proteins that the body perceives as dangerous. Sometimes the antigens are not different enough from the cells around the tumor, however.

The body also often does not categorize tumors as foreign to it. Aggressive immunological attacks, therefore, against the tumor rarely occur. The situation is further complicated because the micro-environment surrounding the tumor is immunosuppressive, which makes it difficult for the immune system to attack the cancer.

Vaccines can stimulate the immune system to recognize the cancer as foreign. Antigen vaccines attempt to get the body to produce antibodies that will try to neutralize the tumor cells. Vaccines can also decrease immunosuppression, alter tumor cells so that they are more likely to be attacked by the immune system, or improve the body's response to chemotherapy. Vaccines may also be used as a preventative measure.

The human papillomavirus (HPV) vaccine is an example of preventative cancer immunotherapy. The HPV vaccine seeks to prevent cervical cancer by protecting the body against the HPV virus. HPV is thought to be the cause of some cervical cancers.

Cancer vaccines can also be made from cancer cells and can be classified as either autologous or allogeneic. Autologous vaccines are created from cells from the patient, custom-made for just for one patient. Allogeneic vaccines are developed from cancer cells from someone else, in a process analogous to how viral vaccines are created.

While active therapy helps the body's immune system to properly respond, passive cancer immunotherapy gives the body man-made antibodies. Monoclonal antibodies (MoAbs or MAbs) are used most often. Antibodies can be given to the patient in two different ways. The first is "naked," which is just the antibodies. The second is "conjugated," in which the antibodies are given to the patient in conjunction with other treatments, such as chemotherapy.

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Discussion Comments


Forgive my ignorance on this subject. I honestly don't know too much about it, aside from what I've read here.

But I'm wondering, if immunity is so important in beating cancer, then why are cancer patients treated with methods like chemotherapy that are known to weaken the immune system?

Is immunotherapy the first stage of treatment where if it fails doctors move on to chemotherapy and similar methods as the patient becomes terminal?


I was so excited to hear about the HPV vaccine because I read that six million new Americans become infected with the virus every single year.

It's really important for women because they can get cervical cancer which is apparently the second deadliest cancer for women now.

I can't get the vaccine since I'm older. But girls and women between 12 and 26 years old can get it. I think it's made up of three doses and you are pretty much protected against cervical cancer for the rest of your life. I'm definitely going to have my girls vaccinated when they are old enough.

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    • Vaccines can help improve a body's response to chemotherapy.
      By: Tsuboya
      Vaccines can help improve a body's response to chemotherapy.