We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What is Bradykinin?

By Erin J. Hill
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Bradykinin is a peptide found within the body that helps to enlarge or open blood vessels. This lowers blood pressure and allows blood to flow more smoothly throughout the body. Many brands of blood pressure lowering medications help to enhance bradykinin production or to keep it from lessening within the body due to certain conditions.

Medical professionals have noted that bradykinin helps to make soft muscle tissue, such as blood vessels, more permeable and allow it to contract and open up. By understanding the body’s own mechanisms for controlling blood pressure, scientists may discover newer and safer ways of treating high blood pressure in patients with chronic conditions.

The discovery of bradykinin was led by Dr. Mauricio Rocha e Silva, along with other researchers in Brazil. At the time they were studying the effects of circulatory shock, primarily that brought on by enzymes commonly found in venom. They discovered it in the plasma of certain animals after being introduced to the venom of a Brazilian lancehead snake, and the resulting effects on blood vessels was noted. This also led to a better understanding of how certain toxins invade the bloodstream so quickly. They generally induce production of bradykinin within the body, thus allowing the venom to circulate more quickly.

In some instances, use of bradykinin-related hypertension drugs, also called ACE inhibitors, may cause a chronic dry cough. This is the number one reason why patients discontinue use of ACE inhibitor drugs. Other medications being offered do not cause this reaction, but they are not as effective, and thus only recommended for those with mild hypertension. Unless the cough becomes severe, patients with chronic or severe hypertension may be advised to continue taking ACE inhibitor medications, sometimes in lowered dosages.

Researchers have also noted a link between an overproduction of bradykinin and the development of hereditary angioedema. Drugs have been created to inhibit production, and have proven effective. There are also natural ways to slow down bradykinin production, including pineapple leaves and stems, polyphenols, and aloe. A doctor should be consulted before large amounts of these substances are consumed, primarily those with high blood pressure.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Discussion Comments
WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.