We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Factors Affect a Sufficient Olanzapine Dose?

By Canaan Downs
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Olanzapine, also known as Zyprexa®, is a member of a class of medication used predominantly to treat the symptoms of schizophrenia. This medication and other atypical antipsychotic drugs in the thienobenzodiazepine drug family should only be prescribed when absolutely necessary, as the side effects of olanzapine can be very serious in some patients. Although generally used to treat the symptoms of schizophrenia, one of the off-label uses of olanzapine is as an adujunct therapy in the treatment of bipolar disorder. When determining the appropriate initial olanzapine dose to use, adjustments must be made according to the age of the patient. Other factors that can affect the suggested olanzapine dose are whether the patient is debilitated, susceptible to lowered blood pressure reactions, uses cytochrome 4501A2 inhibiting medications, or makes adjustments to his or her smoking habits.

When treating schizophrenia in adults, the standard initial olanzapine dose is between 5 and 10 mg orally taken once per day. The maximum daily dose should not exceed 20 mg, allowing for a maintenance dose of 10 mg may to be taken once per day if needed. Due to the serious risks of olanzipine when administered to elderly patients, increases to a daily dose of 5 mg should be carefully considered. This medication should not be used to treat psychotic symptoms associated with dementia, as one of the risks of olanzapine in these patients is sudden death.

The standard initial dose for the treatment of schizophrenia in pediatric populations is much lower than that for adults. An initial olanzapine dose of 2.5 to 5 mg is recommended for patients between eight and 17 years old, although there has yet been little research into its efficacy. This dose can be increased by 2.5 to 5 mg each week to a target dose of 10mg daily. Daily doses should not exceed 20 mg per day.

For patients who are predisposed to hypotensive episodes, an initial daily dose of 5 mg is recommended. Dosage increases should be administered only with caution. The same dosage recommendations should also be used for debilitated patients.

In addition to dementia, the use of olanzapine is contraindicated in patients with Alzheimer's disease, seizures, liver disease, prostate problems, glaucoma, intestinal disease, breast cancer, low blood pressure or a history of neuroleptic malignant syndrome or stroke. The most common side-effects of olanzapine include weight gain, restlessness, dry mouth, irritability, dizziness, sleep disorder, sedation and constipation. One of the most serious risks of olanzapine, however, is tardive dyskenesia, an involuntary muscle movement disorder. This condition is extremely resistant to treatment. Since higher doses of olanzapine increase the risk of developing this condition, it is important to use the smallest effective dose of the drug.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.