We are independent & ad-supported. We may earn a commission for purchases made through our links.

Advertiser Disclosure

Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.

How We Make Money

We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently from our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Are the Different Clomiphene Side Effects?

By Lee Johnson
Updated May 17, 2024
Our promise to you
WiseGeek is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At WiseGeek, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Several different clomiphene side effects have been reported by patients, and these can be classified into common and rare side effects. More common reactions such as drowsiness, nausea, and dry mouth are unlikely to cause serious problems. Rare side effects such as those associated with allergic reaction, restlessness, trouble urinating, and tremors are more serious and affected patients should contact a doctor. There is also an increased risk of suicidal thoughts and behavior in adolescents treated with antidepressant drugs such as clomiphene. The drug is classified as a tricyclic antidepressant, and works on the neurotransmitters within the brain.

The most commonly reported clomiphene side effects include constipation, dizziness, and weight changes. Flushing, blurred vision, and sweating are other common side effects that are not cause for particular concern. These effects should only be reported to a doctor if they are particularly severe or persistent. Many of the common side effects can be managed through lifestyle changes and over-the-counter medicines. For example, patients suffering from constipation can switch to a diet higher in fiber, consume more water than they ordinarily would, or use laxative medicines to manage the problem.

More serious and less common clomiphene side effects are irregular periods, changes in sexual desire, and changes in mood. Confusion, memory loss, hallucinations, and depression fall under the definition of changes in mood. Very serious clomiphene side effects include the yellowing of the eyes or skin, chest pain, seizures, and black, tarry stools. As with most medications, it is also possible to have an allergic reaction, resulting in symptoms such as itching, rash, and swelling of the face. Any side effects not listed on the information leaflet that is provided with the medicine should also be considered serious.

Antidepressant medications such as clomiphene have been associated with suicidal thoughts and behavior in adolescents. This reaction is very rare, but the severity of it has lead regulatory bodies to place warnings on all eligible medicines. Worsening depression or suicidal thoughts are more likely to occur at the beginning of treatment, during any change in dose, or just after dosing has been stopped. Any patients experiencing these side effects should contact a doctor immediately. It is important to note that the medicine will likely not begin to have a positive effect for between two to four weeks.

Clomiphene is classified as a tricyclic antidepressant. Tricyclic antidepressants act on the neurotransmitters serotonin and noradrenaline within the brain, which are believed to affect the mood of the patient. Neurotransmitters are chemical messengers employed by the brain, and some improve mood while traveling between neurons. Drugs such as clomiphene prevent nerves from taking up serotonin and noradrenaline, thus prolonging their mood-improving effects.

WiseGeek is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.

Discussion Comments

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.

WiseGeek, in your inbox

Our latest articles, guides, and more, delivered daily.