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How Effective Is Paroxetine for Premature Ejaculation?

By Lee Johnson
Updated May 17, 2024
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Paroxetine for premature ejaculation is an effective treatment, although it isn’t the primary function of the drug. Studies have shown that taking the drug as needed before sexual intercourse increases the time taken for the patient to ejaculate. The drug taken as needed has been demonstrated to have a better effect on premature ejaculation than a similarly administered placebo or even paroxetine taken daily. This all suggests that paroxetine for premature ejaculation is a beneficial treatment.

Premature ejaculation occurs when a man ejaculates before he or his partner wants it to occur. The condition therefore is quite difficult to define, because if a man takes five minutes to ejaculate, it could be considered premature if he is with a partner who takes 10 minutes to climax, but not if his partner takes only two minutes. Essentially, it is a condition born out of the couple’s perception of the issue rather than an objective measurement of the ordinary amount of time taken to ejaculate. It is the most common sexual problem in men who are less than 40 years old, and it can be either primary or secondary. Primary premature ejaculation occurs from the onset of sexual maturity, and secondary premature ejaculation develops over time.

Using paroxetine for premature ejaculation is not the designed purpose of the drug. Paroxetine falls into a class of anti-depressant drugs referred to as selective serotonin reuptake inhibitors (SSRIs). Serotonin is one of many neurotransmitters that are released by and attach to the nerves in the brain. Doctors believe that an imbalance among these neurotransmitters is the cause of depression. The drug is designed to prevent serotonin from being taken up again by the nerve that produced it, thereby allowing it to stimulate another nerve in the brain.

Studies have shown that the use of paroxetine for premature ejaculation is beneficial, regardless of its intended usage. Researchers have looked at the effects of taking the drug daily or as needed for the treatment of premature ejaculation, and comparison with a placebo has been used to show that the placebo effect was not responsible for the improvement. Paroxetine taken either daily or four hours before intercourse has a beneficial effect on the patient’s premature ejaculation and performs better than a placebo. Results have shown that paroxetine for premature ejaculation is more effective when taken four before intercourse than when taken daily.

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Discussion Comments
By SteamLouis — On Feb 26, 2014

Paroxetine is working well for my premature ejaculation. But for some reason, I'm unable to orgasm and I feel less pleasure. I'm not sure if this drug is a boon or a curse. I'll be looking into other treatments. I'm considering therapy actually because I read that stress is very bad for PE. If I can treat my PE with other remedies/methods, I think I'd prefer to do so. I don't mind taking a medication, I just don't like the other effects.

By ZipLine — On Feb 25, 2014

@literally45-- Paroxetine has potential side effects and libido loss is one of them. It's an antidepressant used to treat depression and anxiety, so it can have other psychological and physical side effects as well.

I was on paroxetine for anxiety, not for premature ejaculation but I saw during my treatment that the medication delayed ejaculation for me. The bad side was that when I stopped taking the medication, I developed premature ejaculation temporarily as a withdrawal side effect.

So I think that paroxetine is not the best premature ejaculation drug. If your doctor approves, you could probably use it once in a while before intercourse. But using it daily and for a long period of time is not going to cure your premature ejaculation. At least I don't think so. Talk to your doctor for more accurate advice, this is just my opinion.

By literally45 — On Feb 25, 2014

I've heard great things about paroxetine for premature ejaculation but I've also heard that it reduces libido. Is this true? If so, does this make paroxetine a good treatment for PE since it reduces sexual desire?

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