Well, it kind of depends on other circumstances. I was stuck in Memphis because of severe weather, and I opted to rent a car one way and go ahead and drive home. It was a three-hour drive, and I made it home before my flight did, by a fair margin. It wasn't the most pleasant trip, because of the weather, but it was still better than sitting at an airport half the night.
I managed to drive out of the rain in about an hour, so it could have been much worse. It was fairly late and no one else was asking for cars, so I got a pretty good deal on the rental.