Medicine
Fact-checked

At WiseGEEK, we're committed to delivering accurate, trustworthy information. Our expert-authored content is rigorously fact-checked and sourced from credible authorities. Discover how we uphold the highest standards in providing you with reliable knowledge.

Learn more...

What is Tylenol® Liver Damage?

Tricia Christensen
Tricia Christensen
Tricia Christensen
Tricia Christensen

Tylenol® liver damage is known as acetaminophen or paracetamol liver damage. Tylenol® is a brand-name for this non-prescription pain reliever that is taken quite commonly; there are other brand-names of medicines that include this drug and there are many prescription pain relievers like Vicodin® or many forms of codeine that contain it too. For years acetaminophen was thought one of the milder drugs on the market, but over time studies suggest that overuse of the drug can lead to life-threatening and sometimes even fatal liver problems.

For people with healthy livers, Tylenol® liver damage becomes a concern only if they exceed the recommended doses of acetaminophen or if they routinely drink more than three alcoholic drinks a day and regularly use Tylenol® as a pain reliever. Under most circumstances a lethal overdose is considered about twice what is normally recommended, but in some people lethality could occur by just taking slightly more acetaminophen than is needed, especially on a regular basis.

People with liver disease, like cirrhosis, are at higher risk for Tylenol® liver damage.
People with liver disease, like cirrhosis, are at higher risk for Tylenol® liver damage.

In Tylenol® liver damage, the liver’s attempt to process high doses may cause creation of a chemical N-acetyl-p-benzo-quinone-imine (NAPQI) that can begin to create rapid damage in the liver. While normal levels of acetaminophen don’t produce this result, especially when a person has a well-functioning liver and is not using large amounts of alcohol, which may suppress some liver function, higher than normal levels have been linked to extremely severe problems.

Overuse of the drug Tylenol® and other pain relievers with acetaminophen can lead to life-threatening and fatal liver problems.
Overuse of the drug Tylenol® and other pain relievers with acetaminophen can lead to life-threatening and fatal liver problems.

The person with initial Tylenol® liver damage may have intentionally overdosed or be unaware of the fact and early symptoms may merely be nausea and vomiting, followed by a period when the person feels better. The third stage if liver damage is severe can cause coma, death, or need for a liver transplant, and since the first symptoms aren’t always identified as Tylenol® liver damage, this could be easy to miss. When caught, in early stages there are interventions that can preserve liver health. It’s always important to mention use of acetaminophen, even it didn’t seem excessive, if severe nausea and vomiting follow it.

Because the liver filters toxins and waste from the blood, if the organ fails to work properly a person can become seriously ill.
Because the liver filters toxins and waste from the blood, if the organ fails to work properly a person can become seriously ill.

There are arguments on the degree to which Tylenol® liver damage should be noted in actual labeling or regarded by the public. Most people suggest that the healthy person is unharmed when using below the maximum recommended dose of the drug. Some feel that the medication should be used only when absolutely necessary and people should take precautions like not using the medicine for more than one day in a row. More agreed upon is that those with liver diseases like cirrhosis or hepatitis are much more at risk and may need to take much less than recommended dosages. More and more, doctors are also agreeing than Tylenol® should not be taken with alcohol.

In severe cases, Tylenol liver damage can result in coma.
In severe cases, Tylenol liver damage can result in coma.

There are so many medications that contain acetaminophen that people should be particularly aware when they use more than one medicine. Things like cold and flu medications may contain Tylenol®, as can prescription pain relievers, tension headache removers and others. Reading labels carefully can help prevent toxicity.

Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent WiseGEEK contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Learn more...
Tricia Christensen
Tricia Christensen

Tricia has a Literature degree from Sonoma State University and has been a frequent WiseGEEK contributor for many years. She is especially passionate about reading and writing, although her other interests include medicine, art, film, history, politics, ethics, and religion. Tricia lives in Northern California and is currently working on her first novel.

Learn more...

Discuss this Article

Post your comments
Login:
Forgot password?
Register:
    • People with liver disease, like cirrhosis, are at higher risk for Tylenol® liver damage.
      By: peterjunaidy
      People with liver disease, like cirrhosis, are at higher risk for Tylenol® liver damage.
    • Overuse of the drug Tylenol® and other pain relievers with acetaminophen can lead to life-threatening and fatal liver problems.
      By: kaianni
      Overuse of the drug Tylenol® and other pain relievers with acetaminophen can lead to life-threatening and fatal liver problems.
    • Because the liver filters toxins and waste from the blood, if the organ fails to work properly a person can become seriously ill.
      By: pixdesign123
      Because the liver filters toxins and waste from the blood, if the organ fails to work properly a person can become seriously ill.
    • In severe cases, Tylenol liver damage can result in coma.
      By: Claudio's Pics
      In severe cases, Tylenol liver damage can result in coma.