What Is Tramadol with APAP?

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  • Written By: Jacquelyn Gilchrist
  • Edited By: O. Wallace
  • Last Modified Date: 08 June 2019
  • Copyright Protected:
    Conjecture Corporation
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Tramadol with APAP is a medication prescribed to treat moderate to severe pain. It is a combination of two different drugs: tramadol and acetaminophen. The former medicine is similar to narcotic pain relievers, while the latter is a non-narcotic pain reliever. Tramadol with APAP works on certain areas of the brain to alleviate pain.

Adults will typically be prescribed a total daily dosage of no more than 300 milligrams (mg). Patients must be careful not to exceed the dosage prescribed by their doctors, because an overdose may be fatal. Tramadol with APAP is not intended for use longer than five days. It may be taken with or without food.

Patients should be aware that tramadol with APAP has the potential to be habit-forming, particularly when it is used for a longer time than recommended. Some people may experience withdrawal symptoms, such as insomnia, anxiety, and uncontrollable shaking, as well as sweating. The doctor may recommend a decreased dosage for a period of time for certain patients before they stop taking the drug.

Some side effects may occur with the use of tramadol with APAP, which should be reported to the prescribing physician if they become severe. Patients may experience dry mouth, increased sweating, and dizziness. Drowsiness and lightheadedness may also occur, along with constipation, nausea, and vomiting. Consuming plenty of water and eating a high-fiber diet may help patients avoid constipation.


More serious side effects may also occur, which require a doctor's immediate care. Patients may rarely experience tremors, vision changes, and fainting. Seizures, shallow breathing, and changes in the amount of urine have also been reported. Other serious side effects may include an unexplained fever, loss of coordination, and severe nausea or vomiting. Hallucinations, rapid heartbeat, and unusual restlessness may occur rarely.

Before using this pain reliever, patients must disclose their other medical conditions. It is strongly recommended that women who are pregnant avoid this drug. Tramadol with APAP may pass into breast milk, so women who are nursing should discuss the risks with their doctors. This drug may be contraindicated for use by those who have kidney or liver disease, pancreatitis, or a history of drug or alcohol abuse. Those with problems urinating, heart problems, or a brain injury or disorder may also be unable to use it.

Tramadol with APAP may interact with other medications. Patients must disclose all other drugs and supplements they take, including recreational drugs, some antidepressants, and St. John's wort. It can also interact with lithium, dextromethorphan, and phenothiazines. A life-threatening interaction can occur when tramadol with APAP is taken within 14 days of taking a monoamine oxidase inhibitor (MAOI).



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