What is the Connection Between CoQ10 and Statins?

The human body produces CoEnzyme Q-10, or CoQ10. Other names for this substance include ubiquinone, ubiquinol, and dimethoxy-t-methyl-6-decaprenyl benzoquinone, as well as many other names associated with particular commercially produced brands. Basic cellular functions involved in the oxidation or conversion of carbohydrates and fatty acids to energy require the presence of this substance. CoQ10 is indispensable in healthy heart muscle function, and it is essential to helping the body's cells produce energy. Multiple research studies suggest that statin drugs taken for high cholesterol might lower CoQ10 levels in the body, creating a negative effect unless supplemental CoQ10 and statins are combined.

Medical evidence confirms that statin drugs do lower total cholesterol and low-density lipoprotein (LDL) levels in most people. A number of studies suggest that these drugs also might decrease the levels of CoQ10 in the blood, possibly increasing cardiovascular risks. This partially negates some of the positive results of the statins. Using CoQ10 supplements to ensure that the patient receives CoQ10 and statins might provide some benefits.

Some individuals, after starting a course of statins, find that they have a reduced tolerance to statin drugs. This resistance might lead to problems such as myalgia, muscle pain, myopathy and muscle weakness. These negative side effects are estimated to appear in as much as 10 percent of all individuals who are taking statins. The use of CoQ10 supplements is believed by many researchers to help alleviate or minimize these side effects.

In rare cases, statins can cause a life-threatening condition called rhabdomyolysis. The results of some small clinical trials suggest that supplementation with CoQ10 might prevent these problems. As of 2010, however, more research was needed before scientists will be able to reach a final conclusion about the effects of CoQ10 and statins. As a dietary supplement, CoQ10 is not regulated in some countries, including the United States.