What Is Sevelamer Hydrochloride?

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  • Written By: Meshell Powell
  • Edited By: Melissa Wiley
  • Last Modified Date: 27 January 2019
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Sevelamer hydrochloride is a prescription medication that is used to reduce the amount of phosphorous in the blood and is used primarily by kidney patients who are undergoing dialysis treatments. This medication is designed to be taken with meals and works by binding phosphates in the diet in order to prevent absorption by the body. Some of the most common side effects of sevelamer hydrochloride include gastrointestinal disturbances, headache, and changes in blood pressure levels. More serious side effects may include respiratory problems or the development of a potentially fatal allergic reaction known as anaphylaxis. Any specific questions or concerns about the use of sevelamer hydrochloride in an individual situation should be discussed with a doctor or other medical professional.

This medication is generally prescribed in the form of a tablet or capsule, and the exact dosage will depend on the individual situation. It is important to take sevelamer hydrochloride exactly as prescribed by a physician. Any questions can be addressed with the doctor or pharmacist.

Phosphorous is normally filtered from the body by the kidneys. In the case of severely diseased kidneys or any medical condition that leads to compromised renal function, the kidneys are unable to properly filter this material from the blood, causing an unsafe buildup of phosphorous. Sevelamer hydrochloride helps to block absorption of phosphorous and prevent buildup. If left untreated, excess phosphorous can lead to health problems such as circulatory calcification and brittle bone disease.


Gastrointestinal problems are the most commonly reported side effects of sevelamer hydrochloride. These symptoms may include nausea, intestinal gas, and indigestion. Vomiting, constipation, and diarrhea are also possible when using this medication. In most situations, these symptoms are relatively mild. In some cases, additional medications may be prescribed to combat these uncomfortable symptoms, and in rare cases, the drug may need to be discontinued.

Some patients may experience changes in blood pressure levels while taking sevelamer hydrochloride, a side effect that must be monitored closely by a physician. Headaches, skin rash, and muscle or joint pain may occur among some people who use this medication. A potentially fatal allergic reaction known as anaphylaxis is rare but demands immediate emergency care should symptoms such as facial swelling, chest pain, or difficulty breathing develop. Any unusual or bothersome symptoms that occur after taking this medication should be reported to a doctor for further medical evaluation to make sure there are no serious complications.



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