What Is Drotrecogin Alfa?

Drotrecogin alfa is a medication reserved for patients who have a very severe type of bacterial infection. A doctor may prescribe it to treat a bacterial blood infection in patients who may be suffering from multiple organ failure and at risk for death. Drotrecogin alfa is only intended to be administered by a doctor, and it is not intended for use by patients at home.

This medication is a form of human activated protein C that works by accelerating the deterioration of blood clots while working to prevent new blood clots from forming, as well as reducing inflammation. Patients will receive this medication through an intravenous infusion via a needle inserted into a vein. Some people may receive the drug over the course of four days while they are hospitalized.

Patients should alert their caregivers at once if they experience any side effects. An allergic reaction may occur, which is typically indicated by breathing problems, swelling of the facial area, and hives. Other potentially dangerous side effects can include bloody urine or stools, bleeding that does not clot, and bleeding from the injection site or any incisions. Some patients have reported vomit with the appearance of coffee grounds, coughing up blood, and slurred speech. Other possible side effects may include stomach pain, confusion, and weakness on one side of the body, along with vision problems.

Certain precautions should be followed while a patient is using drotrecogin alfa. This medication may interfere with the results of some laboratory tests. Patients may need to undergo blood tests and liver function tests for safety reasons. The safety and efficacy of the use of this drug by children has not yet been established and it is also unknown if drotrecogin alfa will harm a fetus or a nursing infant.

Before receiving an intravenous infusion of drotrecogin alfa, patients must disclose all of their other medical conditions. Those with active internal bleeding, severe liver disease, or a blood clotting disorder may be unable to use it. It may also be contraindicated for use by those with a recent history of stroke, blood clots, or head injuries, along with spinal or brain surgery. Patients must inform their doctors if they have any blood vessel problems, kidney problems, or ulcers.

Drotrecogin alfa may interact with other medications and herbal supplements. Those who take anticoagulants, heparin, or salicylates should inform their doctors. It may also interact with streptokinase, platelet inhibitors, and tissue plasminogen activators.