What are the Common Zoloft&Reg; Side Effects?

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  • Written By: Lainie Petersen
  • Edited By: Melissa Wiley
  • Last Modified Date: 26 June 2019
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Like many drugs, users of the anti-depressant drug Zoloft® may experience side effects. Common Zoloft® side effects include difficulty with sexual performance and decreased sexual desire, changes in sleep patterns, and digestive problems. More serious side effects include allergic reactions, bleeding problems, as well as the development of additional psychiatric symptoms.

Some of the most common Zoloft® side effects are sexual in nature. Individuals taking the drug may find that they are not interested in sexual activity. Men can have difficulty maintaining an erection, and women may find it difficult to reach orgasm. For many people using Zoloft®, these side effects induce the desire to quit taking the drug, even though abruptly stopping psychiatric medication is a bad idea. Individuals experiencing sexual side effects should speak to their doctor about lowering their dosage or switching to a medication that is less likely to decrease libido or the ability to perform sexually.

Digestive problems are another class of common Zoloft® side effects and may include nausea, excess gas, and diarrhea. People who take Zoloft® may also experience dry mouth, constipation, and a loss of appetite. In some cases, these digestive systems can result in weight loss. On the other hand, some of the drug's users experience increased appetite while using the drug, so it is important for users to monitor their eating behavior.


Zoloft® side effects can also include sleep disturbances, which can sometimes appear to be contradictory. People using Zoloft® may experience drowsiness, a lack of energy, and tiredness during the day, but may also experience trouble sleeping at night. As changes in sleep patterns and energy levels can affect people's driving, those who take Zoloft® should take particular care when using a car, working with machinery, or engaging in work that requires their full concentration.

Other side effects include headaches, some loss of muscle control, and dizziness. Psychological side effects include irritability, nervousness, and anxiety. While rare, some people experience thoughts of suicide while on Zoloft® or conversely may appear to be inappropriately and unusually cheerful while using the drug. Psychological side effects should be reported to the patient's doctor.

All drugs, including Zoloft®, carry with them the potential for allergic reactions. Symptoms of an allergic reaction can include difficulty breathing, facial swelling, or skin itching. Again, if this occurs, the person using the drug ought to immediately contact his or her doctor or seek emergency medical help.



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