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Is There a Connection between Paroxetine and Weight Gain?

Alex Tree
Alex Tree

All antidepressant medications, including paroxetine, have the potential to cause weight gain. In some cases, this is not a bad thing because it is common for people lose interest in eating due to depression. Other times, the weight gain is attributed to the medication changing the patient’s basal metabolic rate (BMR) or hormones. While there seems to be a definite connection between paroxetine and weight gain, researchers are not sure of the exact link, especially because it is not the same for everyone. Some people experience such drastic weight gain that it is unhealthy and should speak with a doctor.

When depressed, some people lose interest in activities they once loved, like sports and hobbies. It is also possible to lose interest in eating and rarely feel hungry enough to bother. After a week or two of taking antidepressants, many people get their appetites back, which ultimately leads to weight gain. This weight gain might actually be healthy because it helps the person gradually reach his or her normal weight. In this case, paroxetine and weight gain is usually a good sign of recovery.

In some instances, weight gain during the use of paroxetine may indicate that the drug is working because the user's appetite has returned.
In some instances, weight gain during the use of paroxetine may indicate that the drug is working because the user's appetite has returned.

In addition, paroxetine is thought to increase or decrease peoples’ BMR, which is how much energy they use when at rest. It is also believed to have the capability of changing hormones, which can also lead to weight gain. These connections between paroxetine and weight gain are only theories. There are many factors that cause people to gain weight besides the use of paroxetine, making it difficult to study the phenomenon. For example, being depressed despite taking paroxetine, aging, and lack of exercise are common causes.

The exact connection between paroxetine and weight gain remains somewhat of a mystery to researchers. In fact, paroxetine and medications like it were once considered weight-loss drugs. Later, researchers realized that the drug is strongly associated with weight gain rather than weight loss.

Many people gain weight on paroxetine but remain in the normal range for their height and still feel healthy. Other people experience quick weight gain that does not stop and may need to switch treatments. There are plenty of other drugs like paroxetine, which are called selective serotonin reuptake inhibitors (SSRIs). Although paroxetine is one of the most frequently prescribed antidepressant drugs, the side effects can greatly outweigh the benefits for some people. Talking to a doctor about the weight gain and any other side effects that were experienced can lead to a solution.

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    • In some instances, weight gain during the use of paroxetine may indicate that the drug is working because the user's appetite has returned.
      By: Rostislav Sedlacek
      In some instances, weight gain during the use of paroxetine may indicate that the drug is working because the user's appetite has returned.